Before discussing the recent well-controlled and double-blind clinical trials, it is important to make reference to homeopathy’s history in order to provide additional evidence for the clinical efficacy of homeopathic nanopharmacology. Homeopathy first developed a significant popularity in Europe and the United States primarily because of the astounding successes it experienced in treating people suffering from the various infectious disease epidemics in the 19 th century. The death rates in the homeopathic hospitals from cholera, scarlet fever, typhoid, yellow fever, pneumonia, and others was typically one-half to even one-eighth of conventional medical hospitals (Bradford, 1900; Coulter, 1973). Similar good results were also observed in mental institutions and prisons under the care of homeopathic physicians compared to those under the care of conventional doctors. These consistent and significant results could not be attributed to a placebo effect. In other words, there is clear empirical evidence that homeopathic medicines were highly effective in treating various infectious diseases and in psychiatric disorders.